Ubella Vaccine (ra27/3 Strain) in Australian Schoolgir

T he immunogenicity and reactogenicity of the RA27/3 strain of rubella vaccine was evaluated in schoolgirls 11 to 12 years old in a study from April to July, 1987. The incidence of adverse events was lower in initially seropositive girls compared to seronegative cohorts throughout the follow-up period. Overall, 22 per cent of the vaccinees reported symptoms in the first week after vaccination, the most frequent being pain at the site of injection and headache. All initially seronegative girls administered vaccine seroconverted. This vaccine is immunogenic and well-tolerated and can therefore be used without the need for pre-vaccination screening.